Hill Top Chamber斑试器

Hill Top Chamber斑试器

Cliantha Hill Top Chamber斑试器被广泛用于化妆品、香水、薄膜、织物、肥皂、洗涤剂、化学品以及其他可能直接或间接影响或涉及皮肤的产品领域。

Hill Top Chamber斑试器是一种获得专利的闭塞性皮肤传递系统，可用于多种用途，包括：

• 预测性斑贴测试
• 诊断性斑贴测试
• 皮肤水分评估
• 皮肤微生物菌群研究
• 动物身上的斑贴测试

系统设计/方案

Hill Top Chamber斑试器系统的基本组成部分是一个模制的塑料腔室，具有足够的灵活性足以贴合皮肤的轮廓。该腔室有一个独特的双环，由一个外环和一个内部的柔性法兰组成，与皮肤表面紧密贴合，以提高闭合性。在腔室里，一个无纺布的Webril^®垫片容纳试验样品。腔室被夹在方形防粘纸和半封闭的低过敏性胶布之间，随时可以使用。Hill Top腔室可以单独提供，也可以以带有任何数量小室的多体条状形式提供。几乎任何大小或形状的腔室都可以定制生产。也可提供单独的塑料腔室，带或不带Webril^®垫片。

 

腔室组成

Hill Top Chamber斑试器采用壳牌石油公司的产品 Kraton^® G-2705 制造。 Kraton^® 满足或超过当前 USP 对 VI 类聚合物的物理化学和生物测试的要求。该室柔软且有弹性，从而在测试材料和皮肤部位之间提供粘合力。 Kraton^® 材料已获得 FDA 批准使用。可根据客户需求提供其他塑料。 Hill Top Chamber 斑试器系统采用 Durapore^® 背衬，这是一种“丝状”胶带，采用 3M 制造的无乳胶、低过敏性粘合剂，具有高强度和粘合力。 Webril^® 衬垫为 100% 纯棉材质。

 

 

 

腔室尺寸/配置
标准/定制	小室直径	胶带尺寸	腔室容量	当前可选型号*
标准	19 mm 25 mm	3×3 cm 4.5 x 4.5 cm	0.2 ml 0.3 ml	Plain, Plain w/Pad, Full System
定制*	33 mm 52.34 mm	5.5×5.5 cm 7.5 x 5.5 cm	2.0 ml 2.5 ml	Domed Plain

 

*几乎可以定制任何尺寸或形状的腔体。

Hill Top Chambers® 参数表 注意：所有测量值均为近似值，可能略有差异
19mm Chambers Outside diameter – 19mm                                                                                                                                    Inside diameter – 14mm Webril® insert – 0.50 inches (12.7mm) Weight and Capacity without Webril® Weight full at absolute capacity – 0.577 grams Weight empty – 0.273 Volume at absolute capacity – 0.29 ml H2O Weight and Capacity without Webril® Weight full at level capacity – 0.517 grams Weight empty – 0.273 Volume at level capacity – 0.22 ml H2O Weigh t and Capacity with Webril® Weight at full saturation – 0.480 grams Weight empty – 0.297 Volume at full saturation – 0.17 ml H2O	25mm Chambers Outside diameter – 25mm                                                                                                                           Inside diameter – 20mm Webril ® insert – 0.75 inches (19.07mm) Weight and Capacity without Webril® Weight full at absolute capacity – 1.408 grams Weight empty – 0.550 Volume at absolute capacity – 0.86ml H2O Weight and Capacity without Webril® Weight full at level capacity – 1.162 grams Weight empty – 0.550 Volume at level capacity – 0.61ml H2O Weight and Capacity with Webril® Weight at full saturation – 1.158 grams Weight empty – 0.887 Volume at full saturation – 0.27ml H2O
33mm Chambers Outside diameter – 33mm Inside diameter – 26mm Webril ® insert – 0.94 inches (25mm) Weight and Capacity without Webril® Weight full at absolute capacity – 3.995 grams Weight empty – 0.880 Volume at absolute capacity – 3.115ml H2O Weight and Capacity without Webril® Weight full at level capacity – 2.68 grams Weight empty – 0.880 Volume at level capacity – 1.800ml H2O Weight and Capacity with Webril® Weight at full saturation – 2.511 grams Weight empty – 1.010 Volume at full saturation – 1.501ml H2O	52mm Chambers Outside diameter – 52mm Inside diameter – 46mm Webril® insert – 1.73 inches (44mm) Weight and Capacity without Webril® Weight full at absolute capacity – 8.500 grams Weight empty – 1.867 Volume at absolute capacity – 6.633 ml H2O Weight and Capacity without Webril® Weight full at level capacity – 6.612 grams Weight empty – 1.867 Volume at level capacity – 4.745 ml H2O Weight and Capacity with Webril® Weight at full saturation – 5.940 grams Weight empty – 2.238                                                                                                                                Volume at full saturation – 3.702 ml H2O

相关文献:

Quisno, R.A. and R.L. Doyle. “A New Occlusive Patch Test System with a Plastic Chamber.”
Journal of the Society of Cosmetic Chemists, Vol.34 (1983), pp. 13-19.
(http://journal.scconline.org/pdf/cc1983/cc034n01/p00013-p00019.pdf)

Polikandritou, Maria and David L. Conine.
“Enhancement of the Sensitivity of the Buehler Method by Use of the Hill Top Chamber.”.
Journal of the Society of Cosmetic Chemists, Vol.36 (1985), pp. 159-168

Kaminsky, Marvin, Marylou NM. Szivos and Karen R. Brown. “Application of the Hill Top Patch Test Chamber to Dermal Irritancy Testing in the Albino Rabbit.”
Journal of Toxicology –Cutaneous & Ocular Toxicology, Vol. 5 (1986), pp. 81-87.

Donohue, Janet, ed. “SCC Annual Seminar.” Soap/Cosmetics/Chemical Specialties, Vol. 63 (1987), p. 44.

Kim, Hyun Ok and et. Al. “Skin Absorption from Patch Test Systems.”
Contact Dermatitis, Vol. 17 (1987), pp. 178-190.
(http://www.ncbi.nlm.nih.gov/pubmed/3677660)

Nixon, G.A., E.A. Bannan, T.W. Gaynor, D.H. Johnston and J.F. Griffith.
“Evaluation of Modified Methods for Determining Skin Irritation in Animals and Humans.”
Society of Toxicology Annual Meeting, February 1988

Jirova, Dagmar et al. “Comparison of Human Skin Irritation and Photo-Irritation Patch Test Data with Cellular In-Vitro Assays and Animal In-Vivo
Data”. AATEX 14, Special Issue (2007), p. 359-365(http://altweb.jhsph.edu/wc6/paper359.pdf)

York M, Basketter DA, Cuthbert JA, Neilson L.
“Skin irritation testing in man for hazard assessment–evaluation of four patch systems.”
Human Experimental Toxicology. 1995 Sep;14(9):729-34.
(http://www.ncbi.nlm.nih.gov/pubmed/8579884)

Barel, A.O. et al “A Comparative Study of the Effects on the Skin of a Classical Bar Soap in Normal Use Conditions and In the Soap Chamber Test”
Skin Research and Technology 2001; 7, p.98-104
(http://www.healthmegamall.com/Articles/BabeskinArticle189.pdf)

David Basketter, 1 Dagmar Jírova,2 and Helena Kandárová3
“Review of skin irritation/corrosion Hazards on the basis of human data: A regulatory perspective”.
Interdisciplinary Toxicology. 2012 June; 5(2): 98–104
(http://europepmc.org/articles/PMC3485661/reload=0;jsessionid=QSsIUPKZY1p0U7kcIzXX.2)

 

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